Two sample MR report
NQO2_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.3621646 | 0.1585631 | 0.0413749 |
| Weighted median | 14 | 0.0566188 | 0.0196720 | 0.0040003 |
| Inverse variance weighted | 14 | 0.0699751 | 0.0164640 | 0.0000214 |
| Simple mode | 14 | 0.0544099 | 0.0331006 | 0.1241765 |
| Weighted mode | 14 | 0.0513123 | 0.0288637 | 0.0988321 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 13.66782 | 12 | 0.3224220 |
| Inverse variance weighted | 17.57089 | 13 | 0.1745025 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1878262 | 0.1014639 | 0.0889027 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002238 | 0 | TRUE | 0.1591389 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
